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Preimplantation Genetic Test for Aneuploidy

 โพสต์เมื่อ : 15 ส.ค 2568 เวลา 7:10 น.

This test identifies chromosomal abnormalities in blastocyst-stage embryos using Next Generation Sequencing (NGS) technology. After the embryos are cultured to the blastocyst stage, a biopsy is performed by carefully removing a few cells for genetic analysis. The biopsied embryos are then cryopreserved until the results are available.

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Preimplantation Genetic Test for Aneuploidy is suitable for Couples in which the female partner is 35 years old or older Those who have a history of miscarriage Patients who have undergone multiple embryo transfers without success Those who have genetic disorders

Benefits of Preimplantation Genetic Test for Aneuploidy

  • Helps increase the chances of pregnancy

  • Reduces the risk of fetal chromosomal abnormalities during pregnancy

  • Decreases the likelihood of recurrent miscarriage

PGT-A (Preimplantation Genetic Testing for Aneuploidies) is a procedure that screens for abnormal numbers of chromosomes in embryos before they are transferred into the uterus. It is one of the important steps in the IVF (In Vitro Fertilization) process.

Objectives of PGT-A:

  • To detect abnormalities in the number of chromosomes (such as missing or extra chromosomes)

  • To increase the success rate of pregnancy

  • To reduce the risk of miscarriage

  • To select the healthiest embryos before embryo transfer

Steps of the PGT-A Procedure:

  1. Egg retrieval and fertilization in the laboratory

  2. Embryo culture until reaching the blastocyst stage

  3. Embryo biopsy — a few cells are extracted, usually from the part that is not the inner embryo mass

  4. DNA analysis of the extracted cells to examine chromosome numbers

  5. Selection of normal embryos to be transferred into the uterus

Who Is PGT-A Suitable For?

  • Women over > 35 years of age

  • Those with a history of recurrent miscarriage of unknown cause

  • Those who have undergone multiple IVF cycles without success

  • Those who wish to reduce the risk of genetic diseases caused by chromosomal abnormalities

Advantages:

  • Increases the chance of pregnancy per embryo transfer

  • Reduces the number of unnecessary IVF cycles

  • Prevents pregnancies that may be affected by chromosomal abnormalities, such as Down syndrome

Limitations:

  • Cannot detect specific gene mutations (requires PGT-M instead)

  • May involve high costs

  • Carries a slight risk associated with embryo biopsy